Joining Tinoco lab as a postdoc on Jan 2, 2006, I have been working on single-molecule folding and unfolding of RNA using force-measuring optical tweezers.  RNA folding energy landscapes can be probed by mechanical force in near-physiological solutions with various ligands such as protons, salts, small molecules, nucleic acids, and proteins.

Find me in a 2001 picture and Turner Symposium.

This web page is partially supported by Kisha Studio.  

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A molecular map of Mainland China

(1RNK---a ribosomal frameshift inducing virus RNA pseudoknot: Tibet is part of stem 2 shown in green)


 

Publications

During Postdoc training (2006-):

  • Chen, G., Wen, J.D., and Tinoco, I., Jr. (2007) Single-molecule mechanical unfolding and folding of a pseudoknot in human telomerase RNA. RNA 13, 2175-2188. Note

During Graduate Study (2001-2005):

  • Decoding the sequence dependence of base stacking and pairing in       RNA internal loops. To be submitted.
  • JPCB "Norman Sutin Festschrift":Stacking effects on local structure in RNA: Changes in the structure of tandem GA pairs when flanking GC pairs are replaced by isoG-isoC pairs
  • Shankar, N., Kennedy, S. D., Chen, G., Krugh, T. R., and Turner, D. H. (2006)The NMR structure of an internal loop from 23S ribosomal RNA differs from its structure in crystals of 50S ribosomal subunits. Biochemistry45, 11776-11789. (Listed as one of fifteen "Hot Articles" in Nov. 2006 in Biochemistry)
  • Chen, G., Kennedy, S. D., Qiao, J., Krugh, T. R., and Turner, D. H. (2006) An alternating sheared AA pair and elements of stability for a single sheared purine-purine pair flanked by sheared GA pairs in RNA. Biochemistry45, 6889-6903.
  • Chen, G., and Turner, D. H. (2006) Consecutive GA pairs stabilize medium-size RNA internal loops. Biochemistry45, 4025-4043. (Listed as one of four "Hot Articles" in Mar. 2006 in Biochemistry)
  • Chen, G., Znosko, B. M., Kennedy, S. D., Krugh, T. R., and Turner, D. H. (2005) Solution structure of an RNA internal loop with three consecutive sheared GA pairs. Biochemistry44, 2845-2856. (Listed as one of five "Hot Articles" in Feb. 2005 in Biochemistry)
  • Chen, G., Znosko, B. M., Jiao, X., and Turner, D. H. (2004) Factors affecting thermodynamic stabilities of RNA 3 × 3 internal loops. Biochemistry43, 12865-12876.

During Undergraduate Study (1996-2001):

  • Cui, Y., Chen, G., Ren, J., Shao, M., Xie, Y., and Qian, Y. (2003) Solvothermal syntheses of b-Ag2Se crystals with novel morphologies. J. Solid State Chem.172, 17-21.
  • Cui, Y., Chen, J., Chen, G., Ren, J., Yu, W., and Qian, Y. (2001) Bis(2,2-bipyridine-N,N')tetra-m-chloro-tetracopper(I). Acta Crystallogr. Sect. C-Cryst. Struct.Commun.57, 349-351.
  • Shao, M., Mo, M., Cui, Y., Chen, G., and Qian, Y. (2001) The effect of agitation states on hydrothermal synthesis of Bi2S3 nanorods. J. Cryst. Growth233, 799-802.
  • Cui, Y., Ren, J., Chen, G., Qian, Y., and Xie, Y. (2001) A simple route to synthesize MInS2 (M = Cu, Ag) nanorods from single-molecule precursors. Chem. Lett., 236-237.
  • Cui, Y., Ren, J., Chen, G., Yu, W., and Qian, Y. (2000) Poly[lead(II)-m-4,4-bipyridine-N,N'-di-m-bromo]. Acta Crystallogr. Sect. C-Cryst. Struct. Commun.56, E552-E553.
  • Cui, Y., Chen, G., Ren, J., Qian, Y., and Huang, J. (2000) Syntheses, structures and magnetic behaviors of di- and trinuclear pivalate complexes containing both cobalt(II) and lanthanide(III) ions. Inorg. Chem.39, 4165-4168.
  • Cui, Y., Zhang, X., Zheng, F., Ren, J., Chen, G., Qian, Y., and Huang, J. (2000) Two mixed-metal carboxylate-base adducts. Acta Crystallogr. Sect. C-Cryst.56, 1198-1200.

Presentations 

  • Chen, G., Wen, J.D., and Tinoco, I., Jr. (Feb. 2008, Poster) Single-molecule mechanical unfolding and folding of a pseudoknot in human telomerase RNA. Biophysical Society Meeting, Long Beach, CA     
  • Chen, G., Wen, J.D., and Tinoco, I., Jr. (Dec. 2007, Poster) Single-molecule mechanical unfolding and folding of a pseudoknot in human telomerase RNA. Bay Area All RNA Meeting, University of California, San Francisco  PDF
  • Chen, G., Wen, J.D., and Tinoco, I., Jr. (Aug. 2006, Invited Talk) Mechanical manipulation of a pseudoknot from human telomerase RNA. Turner Symposium, University of Rochester
  • Chen, G., Kennedy, S.D., Znosko, B.M., Jiao, X., Krugh, T.R., and Turner, D.H. (Nov. 2005, Talk) Expanded Sequence Dependence Improves Prediction of RNA Internal Loop Stability and NMR Reveals Molecular Recognition Interactions Accounting for Stability, Structure, and Dynamics.RNA Structure and Function Cluster of University of Rochester
  • Chen, G., Znosko, B.M., Kennedy, S.D., Jiao, X., Krugh, T.R., and Turner, D.H. (Oct. 2005, Poster) Improved Thermodynamic Model for Predicting RNA 3 × 3 Internal Loops and NMR Structure of an Unusually Stable Loop with Three Consecutive Sheared GA Pairs. Upstate New York NMR Symposium, Cornell University
  • Wood, A., Chen, G., Krugh, T.R., and Turner D.H. (Mar. 2005, Poster) Thermodynamic Stability of Tetramer RNA Sequences in the Presence of Various Metal Cations. American Chemical Society meeting, San Diego
  • Chen, G., Znosko, B.M., Kennedy, S.D., Jiao, X., Krugh, T.R., and Turner, D.H. (Sep. 2004, Talk) Thermodynamics and NMR of 3 × 3 Internal Loops in RNA. Biological Chemistry Cluster in Department of Chemistry, University of Rochester
  • Chen, G., Znosko, B.M., Kennedy, S.D., Jiao, X., Krugh, T.R., and Turner, D.H. (Aug. 2004, Poster) Improved Thermodynamic Model for Predicting RNA 3 × 3 Internal Loops and NMR Structure of an Unusually Stable Loop with Three Consecutive Sheared GA Pairs. Biological Chemistry Cluster in Department of Chemistry, University of Rochester   PDF
  • Wood, A., Chen, G., Krugh, T.R., and Turner D.H. (Aug. 2004, Poster) Thermodynamic Stability of Tetramer RNA Sequences in the Presence of Various Metal Cations.NSF funded Research Experience for Undergraduates in Department of Chemistry, University of Rochester

Membership

  • American Chemical Society

                Member 2006 -

                Student member 2003 - 2005

  • RNA Society (student member) 2004 -
  • New York Academy of Sciences (student member) 2006 -
  • Biophysical Society 2008 -